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KMID : 0358819910180010013
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Journal of Korean Society of Plastic and Reconstructive Surgeons
1991 Volume.18 No. 1 p.13 ~ p.22
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STUDY ON THE ´TAKE´ OF CULTURED KERATINOCYTE GRAFT
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Abstract
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We cultured the keratinocytes from different donors for 3 weeks and the cultured keratinocyte sheets were applied to the 15 cases of patients who had hypertrophic scars on their extremities. (auto-& allografting). And the applied keratinocyte sheets were studied for the adaptation, growth & differentiation with light and electron-microscopy.
The results were as follows ;
1. Grafted epidermal cells started differentiation from second week post-grafting and showed a similar appearance to the normal epidermis at fourth week post-grafting.
2. Keratohyaline granules were seen from fourth week-post-grafting and showed a normal appearance at fifth month post-grafting.
3. Immature desmosome-tonofilament complexes were seen at cultured epidermal sheet and showed a normal appearance at fifth month post-grafting.
4. Rete ridges showed its appearance at fourth week post-grafting and showed a normal appearance at fifth month post-grafting.
5. Fine structures of epidermo-graft bed junction showed a discontinuous appearance at second week post-grafting and showed a normal continuous appearance at fifth month post-grafting. In summary, the take of grafted epidermal sheets begins at fourth week post-grafting and completed at fifth month post-grafting.
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